Aligning your message to the audience - sounds like a simple task for marketing professionals to be able to apply this concept to their own job search. After all, it's part of what they get paid to do and who would know the them better than themselves? Unfortunately it's not always the case.
I had a post a while back that stressed the need to customize your resume based on the position you are applying for. Create the resume based on research and matching that to your experience to support the job mission. I recently interviewed a candidate I met a couple of years back. Last week we connected on a new position and very different from our original connection.
He did a fantastic job with his research, and his preparation. Although the two positions were drastically different he was able to really hone in on the experience he has and the requirements of the job.
It's clear that having multiple resumes is a necessity but you also have to be sure you don't get caught presenting yourself the same way on each interview. Be sure your preparation for an interview includes not just info on the company. Set aside time to think through a couple of key questions:
How do your experiences line up?
How do you intend to present yourself when you get face to face?
Just like the resume, the interview should be customized to the audience.